Job Description

AbbVie’s Biologics CMC Analytical Research and Development Group in South San Francisco has an exciting opportunity for a Senior Scientist II to join a dynamic team of scientists responsible for all aspects of CMC analytical development   required to move biologic candidates from discovery into and through clinical studies.   

In this lab-based role, you will utilize your knowledge of protein chemistry and expertise in chromatography and capillary electrophoresis to contribute to development of AbbVie’s growing pipeline of clinical stage oncology biotherapeutics, which include novel bispecific constructs, antibody-drug conjugates, and monoclonal antibodies.  You will characterize and investigate attributes of biologic drug candidates to provide product and process understanding, as well as develop innovative analytical methods that provide deeper insights into protein biotherapeutics across the development spectrum from candidate liability screening to process development to clinical development.     

Key Responsibilities Include:

Independently develop state of the art capillary electrophoresis and HPLC methods to characterize biotherapeutic proteins and their associated variants and impurities.

Characterize post-translational modifications and structure-activity relationships of products under development.

Develop innovative approaches to solve difficult analytical challenges.

Represent the Biologics CMC Analytical Research and Development Group as a subject matter expert on cross functional project teams.

Develop, qualify/validate, and transfer fit-for-purpose QC release and stability methods.

Provide technical support and oversight for QC testing occurring at internal and external GMP laboratories.

Plan and author characterization, comparability, and quality sections of regulatory submissions (INDs/CTDs).

Engage and influence the broader scientific community through publications and poster and oral presentations at industry conferences.