Senior Scientist

Senior Scientist
Oxford | On-site | Start-up Biotechnology Company

Talentmark is partnering with an biotech start-up developing next-generation gene therapies for severe genetic diseases. With a highly collaborative scientific team and innovative platform technologies, the company is advancing cutting-edge preclinical programmes focused on delivering transformative therapies to patients with high unmet need. This is a site-based position located at Oxford.

As part of their continued growth, they are seeking a Senior Scientist with a strong track record of managing outsourced pre-clinical studies within the biotech industry. This is an excellent opportunity for someone who enjoys working in a fast-paced, science-driven environment where they can combine scientific leadership, CRO oversight, and hands-on laboratory expertise.

The Opportunity
You will play a key role in driving preclinical in vivo studies through external CRO partnerships, supporting the progression of gene therapy programmes from discovery through translational development. The successful candidate will bring proven experience managing CROs, overseeing in vivo studies, and hands-on wet lab experience collaborating cross-functionally within a biotech setting.

Key Responsibilities

Lead the design, oversight, and interpretation of preclinical in vivo studies with external CRO partners
Manage CRO relationships across study planning, timelines, budgets, protocol review, and data delivery
Act as the internal scientific lead for animal model studies including efficacy, biodistribution, and toxicology
Maintain hands-on involvement in molecular and cellular biology workflows
Support the design and optimisation of gene expression constructs and vector development activities
Contribute to data analysis, project planning, and scientific reporting across multiple programmesYour Background:

PhD in Molecular Biology, Gene Therapy, Immunology, Virology, Translational Medicine, or related discipline
Proven biotech industry experience within preclinical or translational research environments
Strong track record managing CRO-based in vivo studies
Experience with histology, bioanalysis, or biodistribution studies
Experience driving study execution to timelines
Hands-on wet lab expertise in molecular and/or cell biology
Strong scientific data interpretation and problem-solving skills
Excellent project management abilitiesHighly Desirable

Experience within gene therapy, viral vectors, or advanced therapeutics
Exposure to GLP toxicology or IND-enabling studies
Background working with translational animal modelsApply:
It is essential that applicants hold entitlement to work in the UK. Please quote job reference (Apply online only) in all correspondence