Job Description

The Quantitative, Translational, and ADME Sciences (QTAS) department in AbbVie Bay Area (ABA), CA is seeking a highly motivated transporter scientist to join the In Vitro ADME Science (IVAS) group. The QTAS department supports Discovery and Development Projects by generating in vitro ADME data, pharmacokinetics characterization, prediction of human efficacious dose/pk, drug-drug interactions (DDI) and in vitro to in vivo extrapolations towards the development of clinical candidates. QTAS works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, clinical pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings. In this role, the candidate will be responsible for generating in vitro transporter related data and supporting early discovery to late-stage pipeline. The candidate will also could experience the rich culture of our organization. In addition, this role will also enable participation in scientific innovation projects in the field of drug transporters.

Core Job Responsibilities:

· Conducting in vitro transporter experiments using a wide range of in vitro systems such as recombinant transporter and primary cell lines to support pipeline projects in a timely manner

· Cell culture, storage (maintain cell repository-recombinant and primary) and work closely with team members

· Conducting primary hepatocytes-based in vitro uptake experiments

· Conducting HT-screening for potential inhibition of uptake transporters

· Analyzing experimental data and maintaining accurate, and comprehensible study documentations in real time

· Taking part in scientific development goals to improve data quality, capacity, and introducing new tools and techniques