Scientist/Engineer - Process Development Downstream

Posted on Feb 1, 2019 by Bristol-Myers Squibb Company

Hopewell, NJ 08525
Engineering
Immediate Start
Annual Salary
Full-Time
The Scientist/Engineer position in downstream process development will be responsible for conducting research and development that leads to efficient, scalable purification processes for therapeutic molecules. The Scientist/Engineer will be working in a dynamic and collaborative team environment with the opportunities to lead development and matrix teams, while enhancing our ever growing biologics portfolio.

Key Responsibilities:

• Develop and implement scalable purification processes for large molecule drug substance (e.g. monoclonal antibodies, fusion proteins, etc.) to meet established timelines

• Design and execute downstream process development laboratory studies

• Organize and interpret results, present to matrix team and management

• Transfer developed processes from development to clinical production facilities

• Support clinical manufacturing by reviewing documents and/or using technical expertise to ensure successful manufacturing campaigns

• Author electronic notebook records, process descriptions, process development reports, and other documentation/technical reports for progression of assets and/or support of regulatory filings

Preferred Experience and Skills:

• Thorough understanding of/hands-on experience with- purification strategies including: affinity, ion exchange, hydrophobic interaction, and mixed mode chromatography; normal and tangential flow filtration, viral and depth filtration

• Ability to optimize processes for product purity, recovery, impurity removal, and cost reduction

• Experience with scale-up/down process models

• Command of DoE/statistical approaches to experimental design and data analysis

• Experience with high throughput experimentation and mechanistic modelling is desirable

• Ability to train others on procedures, operations, new technologies

• Knowledge of upstream process development and analytical sciences

• Experience with authoring technical documents in support of regulatory submissions

• Experience in technology transfer internally and/or external manufacturing facilities

• Sustain high level of innovative and independent research contributing to platform improvement

• Provide effective management for planning, coordinating and executing tasks and projects in a given time frame

• Outstanding communication and people skills

• Ability to foster a collaborative work environment with internal and external partners

• Experience in leading matrix teams and managing projects is desirable

Qualifications:

• PhD in Biotechnology, Protein Chemistry, Biochemistry or Chemical/Biochemical Engineering, with minimal 2-4 years, or MS with minimal 6+ years, or BS with minimal 8+ years of relevant industrial experience.

Bristol-Myers Squibb is an equal opportunity employer - M/F/Vet/Disability

Reference: 635957826

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