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Postdoc position to study the structural mechanisms of ubiquitin ligas

Posted on Jan 17, 2019 by Rudolf Virchow Center for Eperimental Biomedicine, Wuerzburg, Dr. Sonja Lorenz Laboratory

Würzburg, Bayern Germany
Health Care
10 Dec 2018
Annual Salary
Full-Time
We invite applications for a postdoc position in the research group of Dr. Sonja Lorenz at the Rudolf Virchow Center for Experimental Biomedicine, Würzburg, Germany . The Lorenz lab explores the structural mechanisms of ubiquitin ligases and their functions in tumorigenesis and infectious disease (see eLife 2017;6:e21036 ).
We combine cryo-EM and X-ray crystallography with biophysical, biochemical, and cell biological analyses.
Würzburg has a particularly strong expertise in ubiquitin research , as exemplified by our DFG-funded Research Training Group "Understanding Ubiquitylation":
Moreover, the Lorenz lab is involved in a DFG-research unit "Therapeutic windows"and the Mildred-Scheel Center for Cancer Research, which is funded by the Deutsche Krebshilfe.

Since 2017, our lab also benefits from the EMBO Young Investigator Program . Activities and responsibilities Sucessful candidates will explore macromolecular complexes of ubiquitin ligases by a combination of structural methods, in parcticular X-ray crystallography and cryo-EM.
A large body of exciting preliminary data is available that individual projects can build on. Qualification profile Applicants should have strong expertise in protein X-ray crystallography, biochemistry, and biophysical techniques and a particular interest (ideally, also expertise) in the use of cryo-EM for the visualization of large macromolecular complexes.
English language skills are essential; knowledge of German is not required. Benefits The position can start immediately or upon mutual agreement.
Salary will be according to the German TVL scale. In case of equivalent qualifications, disabled applicants will be preferentially considered.
Würzburg is located in a beautiful, wine-growing area in proximity to Frankfurt (1 hour by train) and Munich (2 hours by train).

Reference: 619562745