Postdoctoral Appointee - Antiviral Engineered Antibodies

Posted on Jan 16, 2019 by Sandia National Laboratories

Livermore, CA 94550
Research & Development
Immediate Start
Hourly Salary
Job Description
This postdoctoral position is a temporary position for up to one year, which may be renewed at Sandia's discretion up to five additional years. You qualify for application if you received your PhD within a five-year timeframe prior to employment.
As a Sandian, in your postdoctoral position, you may bid on regular Sandia positions as an internal applicant. In some cases, a possibility could exist for you to be converted to regular career positions during your term if warranted by ongoing operational needs, continuing availability of funds, and satisfactory job performance.
Sandia/California's Systems Biology Department is seeking a highly motivated biochemist /molecular biologist/immunologist postdoctoral appointee to join a multidisciplinary team using immunotherapy, computational biology/chemistry, high-throughput screening and gene editing to develop medical countermeasures for infectious disease. The successful postdoctoral candidate will help generate, screen, engineer, and optimize therapeutic antibodies using animal models, molecular biology, immunoassays, cell-based assays, and structure based computational design. The successful postdoctoral candidate will also be responsible for the effective communication of research results through publications and conference presentations.
Are you ready for your next challenge? Join this diverse and passionate team of high performing individuals and achieve success while making a difference.
On any given day, you may be called on to:
• Discover and characterize monoclonal antibodies in vitro and in vivo
• Antibody engineering
• Evaluate target antibodies using biochemical/immunological assays, cell-based viral growth assays, and in vivo models of infectious disease
• Perform small to mid-scale protein production and protein purification
• Improve and optimize protein expression and other desired properties of host cells through targeted genetic modifications and other molecular engineering approaches
• Perform in silico docking of antibodies to antigen to identify antibody variants with improved binding affinity and guide antibody engineering
• Data interpretation, manuscript preparation, publication and presentation
Department Description:
The Systems Biology Department performs biological and bioengineering research with applications in national security, healthcare, and alternative energy. The department consists of dynamic, engaged, and passionate team of staff, postdocs, technologists, and students with expertise in microbiology, virology, molecular biology, computational biology, and analytical chemistry. The basic research activities in the department are focused on the identification and characterization of clinical and environmental pathogens, developing a systems-level understanding of host-pathogen interactions, and microbiomes relevant to human health and the environment. Applied research activities are focused on enzyme and microbial engineering for biofuels development, biological detection, and medical diagnostics.
About Sandia:
Sandia National Laboratories is the nation's premier science and engineering lab for national security and technology innovation, with teams of specialists focused on cutting-edge work in a broad array of areas. Some of the main reasons we love our jobs:
• Challenging work with amazing impact that contributes to security, peace, and freedom worldwide
• Extraordinary co-workers
• Some of the best tools, equipment, and research facilities in the world
• Career advancement and enrichment opportunities
• Flexible schedules, generous vacations, strong medical and other benefits, competitive 401k, learning opportunities, relocation assistance and amenities aimed at creating a solid work/life balance*
World-changing technologies. Life-changing careers. Learn more about Sandia at:
*These benefits vary by job classification.
EEO Statement:
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status.
Job Requirements
• PhD in Microbiology, Immunology, Cell and Molecular Biochemistry, Molecular Biology, Cell Biology, Biology or related discipline;
• Hands on expertise performing protein production, protein engineering, protein chemistry and protein purifications (column based methods, gravity flow, FPLC, or HPLC);
• Experience with molecular techniques including PCR, primer design, DNA/RNA sample preparation, molecular cloning, Northern blots, Western blots, and immunoassays (flow cytometry, ELISA, immunocytochemistry);
• Demonstrated record of high technical achievement (e.g. as evidenced by publication in high-impact scientific journals) and the proven ability to conduct creative, independent research.
• Ability to perform routine tasks involved in a virology laboratory, including knowledge of techniques and basic safety procedures in BSL2 (or higher) environment and proper storeage and handling of viruses;
• Proven role as a strong individual contributor within a multidisciplinary team, and within the framework of a research project which shows evidence of meeting deadlines;
• Familiarity with bioinformatics or cheminformatics software tools;
• Experience in computational chemistry, software development and programming (e.g., C/C++, Perl, Python);
• Strong written and oral communication skills;
• Knowledge of general immunology, virology and immune evasion by viruses.
• Experience in assay development, high-throughput screening methods, and animal models;
• Experience in phage display, methods to characterize binding affinity and thermodynamic properties, and label-free technologies for measuring biomolecular interactions (SPR or BLI);
• Protein optimization laboratory research experience, particularly in the production and engineering of antibodies and structural based protein design;
• Familiarity with in vivo methods to measure CNS uptake, including pharmacokinetic techniques (intravenous administration and tissue sampling), brain perfusions, micro dialysis, and imaging techniques.
Security Clearance:
This position does not currently require a Department of Energy (DOE)-granted security clearance.
Sandia will conduct a pre-employment drug testing, and a pre-employment background review that includes personal reference checks, law enforcement record checks, and employment and education verifications. Further, employees in New Mexico must pass a U.S. Air Force background screen for access to the work site. Substance abuse or illegal drug use, falsification of information, criminal activity, serious misconduct or other indicators of untrustworthiness can cause access to be denied or terminated, rendering the inability to perform the duties assigned and resulting in termination of employment.
If hired without a clearance, and one subsequently becomes required or you bid on positions that require a DOE-granted security clearance, a pre-processing background review that includes personal reference checks, law enforcement record and credit checks, and employment and education verifications may be conducted prior to a required federal background investigation. Applicants for DOE-granted security clearances must be U.S. citizens and be able to obtain and maintain the appropriate DOE security clearance as required for the position.
Additional instructions and information:
Please apply at
Please do not forget to mention Bio Careers when applying.

Reference: 615418391

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