Analytical Development Scientist/Sr Scientist

Posted on Dec 12, 2018 by 4D Molecular Therapeutics

Emeryville, CA 94608
Research & Development
4 Dec 2018
Annual Salary
Full-Time
4D Molecular Therapeutics, located in Emeryville is a global leader in gene therapy product research & development using scientific innovation to unlock the full potential of gene therapy for patients with genetic diseases. At 4D Molecular Therapeutics, our goal is to design and develop transformative gene therapy products using our proprietary adeno-associated virus variants platform to treat serious unmet medical conditions. We are seeking a talented and motivated Analytical Development Scientist/Sr Scientist to join our team in developing assays for release, characterization, and process development for novel AAV vectors.

Responsibilities include but not limited to:

Demonstrates innovative design, development and execution of analytical projects through literature review and scientific teamwork.
Leverages strong understanding of analytical biochemistry, including DNA-based assays (qCPR/ddPCR/NGS) and/or protein based assays (HPLC, electrophoresis, ELISAs, CE) as well as cell-based assays, from early development through qualification and validation.
Designs, assesses and interprets experimental data.
May manage Associates in either assay development or assay execution/routine testing.
Reviews data and supports troubleshooting; manages analytical deviations
Leads both from the bench (hands-on laboratory work) and from the desk (designing studies, analyzing data, preparing reports and documents).
May work with CROs on assay development and transfer
Writes assay development reports, assay qualification and validation protocols and reports, and regulatory documents.
Authors manuscripts and presents results at appropriate scientific meetings
Contributes to building a culture that embraces continuous learning, improvement and innovation, and encourages team members to expand their technical skill base and deepen their gene therapy expertise.
Maintains a current awareness and contributes to current scientific literature; actively applies new concepts and technologies as appropriate
Leads and supports research initiatives such as new technology development and continuous improvement projects

Requirements:

PhD (Chemical engineering, Bioengineering, Biology, Biochemistry, Virology, or related field) with 2+ years experience, MS with 5+ years experience, or BS with 10+ years experience in analytical development/QC of large molecule or cellular therapies.
Extensive working knowledge of assay development, including DNA-based assays (qCPR/ddPCR/NGS) and/or protein based assays (HPLC, electrophoresis, ELISAs, CE) and cell-based assays
Strong background in assay qualification/validation
Knowledge of viral gene therapy (adeno associated viral vectors) preferred
Experience managing Research Associates is desired but not required
Successful demonstrated ability to work independently and lead others in designing and developing experiments, analyzing and interpreting data in a rigorous way
Ability to multi-task and support more than one project simultaneously
Ability to work in a team based environment, cooperatively and supportive of multiple viewpoints and approaches
Understanding and knowledge of key scientific software programs
Understanding and knowledge of regulatory requirements for biologic products
Strong organizational skills, analytical and problem solving skills
Strong communication skills both written and oral with demonstrated ability to present ideas and information and data effectively via one on one discussions, team meetings and partnership interactions

Qualified candidates may submit a resume and cover letter to

4D offers competitive benefit and compensation plans as well as an entrepreneurial, collaborative and collegial environment.

Reference: 599254467

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