Postdoctoral position at the NIH

Posted on Jun 18, 2022 by National Institutes of Health

Bethesda, MD 20892
Research
Immediate Start
Hourly Salary
Full-Time

Position type: Postdoctoral position at the NIH

Position Title: Polo Kinases and their associated scaffold proteins orchestrating centrosomal organization, cell division, and tumorigenesis using cell biological, structural, and cryo-EM approaches (cell and structural biology)

Position Description: A postdoctoral position is available to study the function of mammalian polo-like kinase 4 and 1 (Plk4 and Plk1) that play central roles in regulating various biological events, including centriole duplication, bipolar spindle formation, chromosome segregation, cell division, and proliferation. Dysregulation of Plk4/Plk1-dependent processes by mutations in their associated components or HIV accessory proteins, is tightly linked to the development of aneuploidy and cancer. During the past several years, we have been combining biochemical, cell biological, and structural approaches (e.g., super-resolution imaging, in vitro reconstitution, X-ray crystallography, and cryo-EM) to delineate the molecular mechanisms governing Plk4/Plk1's functionality on the centrosomal architecture, the deregulation of which can lead to the development of many human diseases, including cancer, microcephaly, and AIDS. For additional information about our work, please visit .

Applicants should have an expertise in the field of cell biology, X-ray crystallography, or cryo-EM and have a keen interest in learning about the organization/function of the centrosome and their relevance to pathophysiological disorders, such as cancer and AIDS. Applicants with less than three years of postdoctoral training or predoctoral fellows expected to receive a Ph.D. degree are encouraged to apply.

To apply, please send CV and three names of references to Dr. Kyung Lee
( ).
Employer Name: National Cancer Institute, NIH.
Position Location: 9000 Rockville Pike, Bethesda, MD 20892, U. S. A.
Recent papers:
1. Kim, T.-S., et al., 2019. Molecular architecture of a cylindrical self-assembly at human centrosomes. Nat. Comm. 10: 1151. Featured article (Editors' Highlights).
2. Park, J.-E., et al., 2019. Phase separation of polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis. Nat. Comm. 10: 4959.
3. Wei, Z., et al., 2020. Requirement of the Cep57-Cep63 interaction for proper Cep152 recruitment and centriole duplication. Mol. Cell. Biol. 40:e00535. Featured article (Cover art)
4. Ahn, J. I., et al., 2020. Phase separation and versatile capacity of pericentriolar scaffold proteins drive the formation of higher-order self-assemblies at human centrosomes. Cell Cycle.
Nov 18:1-21.
5. Lee, K. S., et al., 2020. A self-assembled cylindrical platform for Plk4-induced centriole biogenesis. Open Biol. 10:200102 (Review). Featured article (Cover art)
Disclaimer: This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.

Reference: 1633776276

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