Scientist I

Posted on Nov 15, 2018 by Frederick National Laboratory for Cancer Research

Frederick, MD 21701
Research & Development
6 Nov 2018
Annual Salary
Full-Time
The Clinical PD Biomarkers Program is responsible for identification of biomarkers of response to new targeted agents entering clinical trials in the Developmental Therapeutics Program of the National Cancer Institute. The scope of work includes assay design, development, validation, fitness for purpose testing, transfer of assays to clinical laboratories, and clinical specimen analysis when required. The program facilitates mechanistic and performance analysis of putative anti-cancer agents, diagnostic tests, and therapeutic interventions to clinical applications, including distinct molecular signatures for cancer, refined molecular assays, and state-of-the-art imaging techniques that are too high-risk for industry or academia to pursue. The program operates a number of advanced, specialized instrumentation for image analysis of tumor biopsies, circulating tumor cells, and activated Tcells for measuring drug effects in patients enrolled in clinical trials.KEY ROLES/RESPONSIBILITIESThe Scientist will: Design, perform, analyze, and present in vitro experiments to test pharmacodynamic marker responses to novel anti-cancer therapeutics in multiple formats, but particularly in multiplex immunofluorescence analysis of circulating tumor cells and activated T cells Generate materials and data necessary to support the primary experimental objectives of the program Support development and implementation of multiplex immunofluorescence assays in support of clinical studies and initiatives Design experiments and strategies to test and confirm putative mechanism of action of clinical trial candidate compounds Perform data analysis and reporting of results from clinical specimen biopsies to the NCI BASIC QUALIFICATIONS Possession of a Doctoral degree from an accredited university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency No experience beyond the doctorate is required Demonstration of specific training in cancer biology, biomarker development, or drug screening strategies is required Experience in the design and validation of multiplexed immunofluorescence assays and the ability to work across testing platforms during the assay development process Experience with quantitative image analysis software (e.g., Definiens) Experience with flow cytometry, imaging flow cytometry Design of cell-based assays to test mechanism of action of candidate compounds Ability to master novel technologies and instrumentation in response to changes in project priorities or breakthrough technological innovations; hands-on instrumentation work is required for this position Ability to communicate with program lead researchers in a demanding scientific environment through preparation of formal reports is essential Ability to maintain precise records Must be able to obtain and maintain a security clearance PREFERRED QUALIFICATIONS Experience in isolation and characterization of individual target cells A record of publication in refereed scientific literature Completion of related post-doctoral research and/or training Expected Competencies: pharmacology; cancer biology; high content image analysis; flow cytometry; image analysis; T cell biology; fluorescence microscopy Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

Reference: 569310069

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