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Scientist/Sr Scientist AAV Cargo Development and Screening

Posted on May 25, 2021 by Capsida

Newbury Park, CA 91320
Immediate Start
Hourly Salary

Job Description

Capsida: Scientist/Sr Scientist AAV Cargo Development and Screening

We are a fully integrated AAV engineering and gene therapy company poised to create the next generation of innovative genetic therapies, with life-changing potential for patients with grievous unmet medical needs.

We leverage our proprietary high-throughput AAV engineering platform to create viral vectors with cell-type and tissue level specificity, overcoming many of the biological limitations of early gene therapy efforts. Combined with our in-house preclinical and manufacturing expertise, we are positioned to create the next generation of AAV delivered gene therapies, dramatically changing the lives of patients.

We are founded on the idea that diverse backgrounds and skill sets combine to create an environment that stimulates innovation and creativity, enabling us to grow into a leader in the AAV gene therapy space. Our leadership team is comprised of the scientific founders that developed the underlying intellectual property, and experienced industry veterans with a track record for bringing transformative drugs to market. Together with our partners, we will combine next generation engineered capsids with cutting edge gene editing and delivery modalities to bring novel medicines to patients that need them. Our research and development labs, offices, and manufacturing space are located in Newbury Park, near the Amgen campus.

The Role:
We are looking for scientists to work on our cargo development team. Members of this team will be responsible for conceiving, screening, and confirming in vitro efficacy of cargos for the entire range of products in the Capsida gene therapy pipeline. Successful candidates will have experience with one or more of the following: regulatory element library construction and screening, shRNA design, cell line development and screening, iPSC disease models, high-throughput screening, NGS and single-cell omics. This position will require the applicant to work with multiple collaborators to design and execute projects, as well as directly manage research associates. Laboratory activities are expected to constitute approximately 80% of the time.

Some team members will be responsible for the design and screening of libraries to identify and modify cargo constructs through early research to the selection of development candidates. Other team members will be responsible for the design and execution of iPSC-based assays leading to the selection of development candidates.

All team members will be responsible for the following:
Collaborations both within the cargo team for measuring efficacy of constructs, as well as with other teams at Capsida, including the high-throughput sequencing core, AAV production, and capsid engineering.
Keeping up to date with novel tools for gene expression, library construction, cell line development, and screening.
Present findings to interdisciplinary scientific teams to seek input on key studies and propose data-driven decisions.
Develop a small scientific team, coordinate their efforts, and see to their own scientific and professional improvement along with your own
Job Requirements

PhD in molecular or cell biology, or a related scientific discipline.
Master's degree in molecular or cell biology, or a related scientific discipline with 4 or more years of post-doctorate or industry experience.
Technical experience with DNA assembly methods, library design, and assay development - or - Technical experience with biochemistry/molecular biology analysis in primary neuronal cell culture or iPSC-derived neuronal cell culture.
Experience with NGS sample preparation and related data analysis.
Experience with high-throughput DNA screens.
Demonstrated capability of generating data-driven hypotheses and designing/developing properly controlled studies/assays for hypothesis testing.
Excellent oral and written communication skills.
Collaborative mindset and a willingness to work with and provide mentorship to junior RAs.
Thrives in a dynamic and fast-paced research environment.

Preferred Qualifications:
Experience with viral delivered gene therapy constructs.
Experience with cell culture-based screens.
Experience with single cell assay platforms, such as ddPCR, 10x or Mission bio.
Experience with gene expression modulation.
Please do not forget to mention Bio Careers when applying.

Reference: 1205946145

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