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Scientist I/II, Purification

Posted on Apr 19, 2021 by Bevov

Santa Clara, CA 95053
Research
Immediate Start
Annual Salary
Full-Time


Job Description Our client is looking for a highly motivated and enthusiastic scientist to join the company's research drug discovery efforts and lead our biologics purification platform and research capabilities. S/he is expected to help champion purification & characterization efforts of lead LYTAC programs. A successful candidate has a thorough knowledge of purification theory and a demonstrated history advancing research molecules into pre-clinical development. Responsibilities



  • Purification of lead/reagent antibodies from mammalian tissue culture (hybridoma, 293, CHO)

  • Purification of recombinant proteins for research pipeline/assay development including soluble ligands and extracellular domain fusions

  • Expert in FPLC-AKTA / Unicorn software station and process flows

  • Expert in Affinity purification (protein A, His-tag, FLAG-tag)

  • Expert in protein chromatography (Gel filtration, IEX, HIC, multi-modal resins), and applicability from mg to gram scale

  • Purification of LYTAC conjugated biomolecules (non-specific and site-specific conjugation chemistries)

  • Early formulation development for lead LYTAC programs

  • Work independently on the design, execution, and interpretation of experimental results.

  • Coordinate activities with functional groups and project teams

  • Analyze, document, and report data concisely and rigorously.

Qualifications

  • Ph.D. in biophysics, biochemistry, or related field, with relevant post-doctoral research or MS with 10 years of industry experience

  • Demonstrated history of accomplishments via high impact publications and/or advancing molecules from research into pre-clinical/IND activities

  • Candidates with relevant industry experience will be given preferential consideration for this position

  • Experience in a wide variety of analytical and physicochemical techniques including chromatography (High- Performance Liquid Chromatography: HPLC, Capillary Electrophoresis: CE), Surface Plasmon Resonance (SPR - Biacore and/or Octet), Light scattering (DLS/MALS), LC/MS characterization

  • Working knowledge of bi-specific antibody designs

  • Acute attention to details, well-organized, diligent with documentation

  • Highly goal-driven and displays the ability to handle delicate experiments in a timely manner

  • Able to operate in a collaborative environment and communicate clearly and concisely, both verbally and in the form of written reports

Benefits Our client is an equal opportunity employer and value diversity at their company. They do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status

Reference: 1171234852

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