Scientific Director, Biomarkers Hepatitis, Belgium

Posted on Nov 22, 2020 by Elevate Direct

Beerse, Antwerpen, Belgium
Immediate Start
€90k - €120k Annual

Functions: R&D Late Discovery and Early Clinical trials

Job Description

The Infectious Diseases Biomarker group is recruiting for a Scientific Director Biomarkers Hepatitis, located in Beerse, near Antwerp (Belgium) to support Janssen's exciting portfolio of assets in HBV.

The Infectious Diseases (ID) Therapeutic Area of Janssen R&D is pioneering new treatment paradigms and has various assets in late discovery and clinical development. The ID Biomarkers team develops and executes on strategies that identify and implement novel biomarkers that aim to improve our understanding of the disease and of treatment efficacy and safety in late discovery and early clinical trials, to support clinical proof of relevance of novel treatment modalities, and to effectively enable stratification of patient segments according to disease subtypes and medical need.

We are currently looking for highly motivated candidates with the following profile:


Lead a small team of scientists that plays a leading role in the design and execution of meaningful biomarker identification and implementation strategies during the different trajectory stages of discovery and clinical development of novel treatment modalities, in particular in the context of viral hepatitis B disease.

Development and timely execution of specific biomarker plans in the various projects through partnering with various stakeholders in hepatitis project teams and scientists in the ID Biomarkers team. Describe the biomarker needs in projects and propose the most appropriate technical-scientific approaches that can address these specific needs.

Identify and validate novel prognostic and predictive biomarkers (signatures) from high-dimensional biological data generated from internal projects and/or external data sources. Deliver biomarkers that impact on the progression and the delivery of the hepatitis programs.

Drive scientific collaborations with external partners to develop novel insights from clinical samples into hepatitis disease biology and patient segmentation.

Combine hepatitis disease knowledge with data analysis and statistical expertise to characterize disease mechanisms, mode of action for therapeutic interventions, and candidate biomarkers for the hepatitis disease area stronghold. Drive data integration, analysis, and interpretation of high-dimensional data from a variety of platforms including next-generation sequencing, gene expression platforms, flow cytometry, CyTOF, single cell NGS, proteomics, and spatial omics (IHC/ISH).

Collaborate with Computational Sciences, Data Sciences, Quantitative Sciences, and R&D IT to implement data analysis approaches that address the biomarker needs for the hepatitis programs.

Communicate and report (oral and written) on the scientific progress of biomarker research in the hepatitis programs to the various stakeholders, senior leadership, and external scientific community as appropriate.

Additional proficiencies

PhD, MD or MD/PhD in translational sciences or equivalent, with proven experience in biomarker research in the field of hepatitis, immunology, or immune-oncology.

Minimum of 10 years of industry or relevant experience where direct hands-on' experience in biomarker research is required.

Track record of developing and implementing impactful biomarker plans for discovery and clinical development programs is essential.

Demonstrated experience with fit-for-purpose biomarker research platforms (genetic, transcriptomic, proteomics, cellular profiling, single-cell level, ...) in the setting of human translational studies, preferably in the context of infectious diseases or immunology.

Depth of expertise in the development and implementation in clinical studies of validated biomarker assays for the analysis of both peripheral and tissue samples.

Knowledge and understanding of the regulatory, legal and operational requirements of sample collection (biobank) and data handling for biomarker analyses in clinical studies.

Decent understanding and insight in the selection and application of computational methodologies appropriate for high-dimensional data analysis in biomarker research.

Supervisory experience and working in project teams is required

Solid written and oral presentation skills, with a convincing record of peer-reviewed publications and presentations at scientific conferences. Ability to clearly articulate scientific and operational concepts of biomarker research across functions, levels, and disciplines.

Good planning, prioritization, problem solving, and organizational skills.

Resilient, energetic, and enthusiastic; responding constructively to challenging new ideas and inputs.

Our offer

An exciting position in an international and dynamic environment with continuous learning and growth opportunities

Working on a site that harbors all aspects of the drug discovery process, located close to the vibrant city of Antwerp.

An attractive remuneration package with multiple extra-legal benefits (for example hospital insurance, onsite gym facilities, and other health care incentives)

An inclusive team environment where diversity and different opinions are respected and valued, and the importance of a good work-life balance is recognized.

Working schedule:

Candidates are expected to be permanently based near the J&J site in Beerse, Belgium. There is some flexibility on remote working 2-3 days per week.


100% Full company pension plan entry. There is no Employee contribution necessary.

Company car allowance.


Total 38 days in Belgium.

If you match these requirements, please apply as usual. Elevate will send you an email, please open, click and action it and your application will be visible to the hiring organisation directly. Elevate provides a route to contract and contingent assignments across many skills areas by matching your profile to relevant jobs that our customers post to the platform.

Please note that Elevate Direct is a software provider and not a recruitment agency. As such, Elevate is not involved in the recruitment processes for any employer, who uses the platform. Please contact employers directly through your Elevate profile with any queries related to your application.

Reference: 1014111597

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