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Team Lead - Protein Technologies

Posted on Feb 11, 2020 by Michael Bailey Associates - Munich

Lausanne, Vaud, Switzerland
Research
1 Apr 2020
Annual Salary
Full-Time

We are working with an exciting new client on a huge opportunity for Scientists of all levels to participate in the research and development of next generation of multispecific antibodies for Immuno-Oncology, inflammatory diseases and autoimmune diseases.

We are looking for a Team Lead in Protein Production for discovery projects. The successful candidate will have expertise and substantial experience in mammalian cell culture, antibody expression and purification, antibody characterization and a strong interest in developing biotherapeutics Immuno-Oncology and Autoimmune diseases.

Responsibilities:

  • Establish a highly functioning protein technology group
  • Lead protein production group to generate antigens and antibodies to support discovery research and support projects
  • Utilize and develop novel technologies/methodologies to express and purify antigens including difficult to express proteins
  • Implement and supervise protein purification automation
  • Implement and supervise early protein analytics of innovative antibody formats
  • Leverage mammalian antibody expression platforms to facilitate discovery research.
  • Be an effective leader and mentor principal scientists, research officers and associates as well as work in multidisciplinary discovery team.
  • Accomplish goals under project team timelines
  • Interface with multiple discovery project and Matrix teams across the organization

Requirements:

  • Ph.D. in Biochemistry, Structural/Molecular Biology, or related field with at least 6 years of relevant industrial experience in a similar role
  • Extensive experience in leading a core group of scientists to make high quality proteins for in vitro and in vivo testing
  • Strong knowledge and experience in making proteins and antibodies from multiple species
  • Strong expertise in mammalian cell expression (HEK and CHO) and bispecific technologies is required
  • Strong hands-on experience with multiple expression systems/formats (mammalian, insect, yeast, and E. coli) and purification media (affinity, ion-exchange, hydrophobic, size-exclusion chromatography) and automation is required
  • Demonstrated ability to make complex antigens like multi-transmembrane receptors, oligomers, and difficult to express and purify proteins
  • Demonstrated ability to generate proteins for x-ray crystallography and cryo-EM
  • Experience in generating cell-lines (electroporation, viral transduction, transposons etc.) is also required
  • Experience in evaluating antibody liabilities and formulations is highly desirable
  • Excellent hands-on knowledge of antibody analytical methods
  • Demonstrated ability to work in a multidisciplinary biologics discovery team
  • Superior Project Management/Project Leadership skills
  • Ability to manage multiple priorities and align internal and external stakeholders

Get in touch Luchele Mendes

Michael Bailey International is acting as an Employment Agency in relation to this vacancy.

Reference: 842227324

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